Endocrine Abstracts

Aim: It is well known that there is a strong relationship between chronic inflammation and tumorigenic process. The cytological diagnosis of follicular neoplasm (FN) carries a 20–30% risk of malignancy for thyroid nodules. In this study, we aimed to evaluate whether preoperative neutrophil to lymphocyte ratio (NLR) is a predictive factor for malignancy in thyroid nodules diagnosed as FN on cytology.Materials and methods: A total of 139 patients with...

Addison’s disease (AD), is an autoimmune disorder. However, its association with connective tissue diseases is rare. Here, we report a case of AD associated with ankylosing spondylitis (AS).Case: A 57-year-old male patient admitted to internal medicine polyclinic with complaints of debility and anorexia. In the physical examination, he has hyperpigmentation on his skin, gingiva and palm lines. Blood pressure was 80/50 mmHg, pulse was 64/min. The oth...

Aim: Diabetic foot is a devastating complication of diabetes mellitus. Many factors such as neuropathy, vascular injury and infection contribute in the development of diabetic foot. Programmed cell death is a pathway that causes a tendency for the development of atherosclerosis. Whereas Fas/Fas ligand pathway induces apoptosis, osteoprotegerin (OPG) causes calcification in vascular area and also effects apoptotic pathway. In the present study, we aimed to investigate the role ...

Aim: Acromegaly is associated with accelerated atherosclerosis and cardiovascular disease. Nitric oxide (NO) is enzimatically formed from L-arginine by endothelial nitric oxide synthase (eNOS). Several studies have shown that reduction in NO synthesis causes endothelial dysfunction and impaired endothelium-dependent vasodilation. Asymmetric dimethylarginine (ADMA), the endogenous inhibitor of NOS, accumulation plays a prominent role in the pathogenesis and in pr...